In the cohort of long-living individuals, no reportable variants were found in FBN1 (AF in the general population sample = 0.0000399), TGFBR1 (AF = 0), TGFBR2 (AF = 0), SMAD3 (AF = 0), TNNI3 (AF = 0), ACTA2 (AF = 0.0000200), CASQ2 (AF = 0.0000266), TNNT2 (AF = 0), FLNC (AF = 0.0000266), BAG3 (AF = 0.0000067), COL3A1 (AF = 0.000107), PCSK9 (AF = 0), TPM1 (AF = 0.0000133), and PRKAG2 (AF = 0.0000067). The gene discussed is ACTA2; the disease is atrial fibrillation.