Cell adhesion molecule 1 (CADM-1), also known as the tumor suppressor in lung cancer 1 (TSLC1) or immunoglobulin superfamily member 4 (IGSF4), is a cell adhesion molecule that is expressed in most cell types, except for peripheral blood lymphocytes, and is thought to function as a tumor suppressor in a variety of cancers [299,300]. Here, CADM1 is linked to neoplasm.