Virus infection is detected by pattern recognition receptors (PRRs), including various types of Toll-like receptors (TLRs) and activates IRFs by phosphorylation through IRF kinases, such as TANK-binding kinase 1 (TBK1), transforming growth factor beta-activated kinase 1 (TAK1) and IKKε. The gene discussed is TBK1; the disease is viral infectious disease.