FOXO3 and neurodegenerative disease: In order to address the epigenetic effect of Neurofabine-C, crucial genes were analyzed such as Forkhead Box O3 (FOXO3) that plays a central role in neuroprotective pathways, ATM (ataxia telangiectasia, mutated), another key DNA repair regulator and HIF-1α, elevated expression of which is linked to neurodegenerative diseases, inflammatory processes, and post-stroke pathology.