Conversely, in HCC, these macrophage-to-neutrophil interactions were markedly reduced, and a subset of immunoregulatory signals—such as TGFB1–TGFBR1/2 and PTPRC–MRC1—mediated from neutrophils to macrophages became further restricted. This evidence concerns the gene TGFBR1 and hepatocellular carcinoma.