The ROGDI−/− knockout mouse model develops ROGDI-RD-like symptoms such as epilepsy, memory impairment, and amelogenesis imperfecta with severe enamel hypomineralization, also suggesting a role for ROGDI in the regulation of lysosomal acidification due to decreased V-ATPase activity caused by impaired Rabconnectin-3 complex [10,11]. This evidence concerns the gene DMXL2 and epilepsy.