Results obtained within this study indicate that the presence of deletion within the NKG2C/KLRC2 gene, as well as NKG2A rs7301582, HLA-E rs1264457, MICB rs065075, and MICA rs1051792 SNPs, could be associated with COVID-19 susceptibility and the severity of the disease. This evidence concerns the gene KLRC2 and COVID-19.