Today, in addition to TNF-a inhibitors, there are biologic agents that specifically target cytokines such as interleukin-17A (IL-17A) and its receptor (IL17RA), interleukin-17F (IL-17F), interleukin-23 (IL-23), interleukins 12/23 (IL-12/23), and the interleukin-36 receptor (IL-36R), with the latter being targeted in generalized pustular psoriasis [2]. This evidence concerns the gene IL37 and psoriasis 14, pustular.