It was determined that 57.1% of patients with RPGR mutations had high myopia (mean refractive error of the entire RPGR cohort was −5.29 D +/− 4.16 D; range from +1.50 D to −10.75 D), and 2 female patients with de novo RPGR variants had retinitis pigmentosa or cone-rod dystrophy along with high myopia. Here, RPGR is linked to Cone rod dystrophy.