In line with these findings, Skripka A. et al. (2024) in a cohort of 84 AF patients treated with apixaban also found no significant associations between ABCB1 rs1045642, rs4148738, CYP3A4*22, or CYP3A5*3 variants and either bleeding events or C/D values [17]. This evidence concerns the gene CYP3A4 and atrial fibrillation.