HMGCR and Alzheimer disease: For instance, variants within or near PTEN, HMGCR, and NFKB1 have been linked to AD and PD susceptibility [82,91,104,105], while TBK1, which is a key immune and autophagy regulator, is said to be linked in ALS, wherein loss of function mutations could possibly disrupt protein clearance pathways [73,74].