SCN1A-related disorders encompass a broad phenotypic spectrum, ranging from mild presentations, such as simple febrile seizures and generalized epilepsy with febrile seizures plus (GEFS+), to severe conditions like DS and intractable childhood epilepsy with generalized tonic–clonic seizures (ICE-GTC) [4,18,19]. This evidence concerns the gene SCN1A and idiopathic generalized epilepsy.