Additionally, WWOX missense variant (p.L239R) identified in patient (case #49) from a consanguineous family was linked to hypsarrhythmic EEG patterns and multifocal seizures consistent with previous reports emphasizing the gene’s role in early-onset epilepsy and poor neurodevelopmental outcomes and linking to WWOX-related epileptic encephalopathy (DEE28 or WOREE syndrome) [27]. Here, WWOX is linked to developmental and epileptic encephalopathy, 28.