High FAM72B expression was correlated with improved prognosis in ovarian cancer (OS: HR = 0.73, 95% CI = 0.55 to 0.96, p = 2.4e−2; RFS: HR = 0.66, 95% CI = 0.44 to 0.98, p = 3.9e−2), STAD (OS: HR = 0.66, 95% CI = 0.46 to 0.94, p = 2.2e−2; RFS: HR = 0.4, 95% CI = 0.16 to 1.03, p = 4.9e−2), esophageal squamous cell carcinoma (ESCC) (OS: HR = 0.23, 95% CI = 0.1 to 0.57, p = 5.7e−4), and THYM (OS: HR = 0.07, 95% CI = 0.01 to 0.6, p = 1.7e−3). This evidence concerns the gene FAM72B and ovarian cancer.