HMGB1 and cancer: In addition, FAM72B expression was generally positively related to inhibitory checkpoints like CD276, TGFB1, and VEGFA, and stimulatory checkpoints like HMGB1, TNFSF4, ICAM1, and CXCL10 in most cancers, particularly with HMGB1 showing a positive relation to all of those mentioned except for READ, COADREAD, and COAD (Figure 8J).