FAM72B and cancer: Given that the Wnt/β-catenin signaling pathway plays a crucial role in biological processes such as cell proliferation, differentiation, and migration, its abnormal activation in KICH may not only promote malignant behaviors of cancer cells, such as proliferation and invasion, but may also indirectly lead to the downregulation of FAM72B expression by disrupting the normal mechanisms of gene expression regulation [58].