On one hand, DLGAP5 directly interacts with E2F1 and stabilizes it by inhibiting its ubiquitination through the deubiquitinating enzyme USP11, thereby forming a DLGAP5-USP11-E2F1 feedback loop that promotes the proliferation and migration of bladder cancer cells and drives the progression of bladder cancer [105]. This evidence concerns the gene E2F1 and urinary bladder cancer.