Recent studies have, for the first time, identified SPAG5 as a direct transcriptional target of the YAP-TAZ-TEAD axis and a direct target of miR-10b-3p, elucidating the mechanism by which the YAP-TAZ-TEAD axis in the Hippo signaling pathway upregulates SPAG5 expression by inhibiting miR-10b-3p, thereby promoting the proliferation and migration of breast cancer cells, and thus providing a novel therapeutic target for the treatment of breast cancer [104]. The gene discussed is SPAG5; the disease is breast carcinoma.