The results showed that FAM72B expression was predominantly positively associated with most immune checkpoints in UVM, PAAD, MESO, LIHC, KIRP, CHOL, THCA, PCPG, LGG, BLCA, KIRC, OV, GBMLGG, PRAD, KIPAN, and BRCA, and the association was specifically exclusively positive in MESO, CHOL, PCPG, and OV, but predominantly negative in THYM, neuroblastoma (NB, from the TARGET database), and LUSC. The gene discussed is FAM72B; the disease is neuroblastoma.