The biosynthesis of fatty acids in goose liver is catalyzed sequentially by enzymes that are reflected in the activation of key genes during the reversible process of hepatic steatosis in geese, including ME1 (malic enzyme 1), SCD1, ACSL1 (acyl-CoA synthetase long-chain family member 1), and ELOVL6 (elongation of very-long-chain fatty acids protein 6). This evidence concerns the gene ACSL1 and fatty liver disease.