CHRM5 rs7162140, the only common polymorphism in the locus s (minor allele frequency 9% overall; 21.7% in Europeans), has been linked to addictive behaviors that may increase cardiometabolic risk [21,22], and in our study was associated with T2D, SIRD, and MOD, suggesting contributions via metabolic and behavioral pathways. The gene discussed is CHRM5; the disease is type 2 diabetes mellitus.