Both serum wheat-sIgE and ω5G-sIgE (ω-5 gliadin specific IgE) prove to be comparably moderate-accuracy diagnostic biomarkers for IgE-mediated wheat allergy, with the slightly higher sensitivity of ω5G-sIgE making it especially useful for identifying challenging cases such as WDEIA and adult-onset wheat allergy [39,40]. Here, IGHE is linked to wheat allergic reaction.