FOXO3 and premature menopause: In a study conducted by Zhang et al. in rats with premature ovarian failure (POF) miRNA-190a-5p showed a significant differential expression profile in POF cases because it continuously activate primordial follicles in rats by targeting the expression of the PH site and leucine-rich repeat protein phosphatase 1 (PHLPP1) gene in both protein kinase-B transcription factor protein O3 (AKT-FOXO3a) and AKT-luteinizing Hormone/Luteinizing Hormone Receptor (AKT-LH/LHR) pathways.