The concentrations of Hb (≤11.5 g/dL), platelets (≤100∙103/mm3), IgM (>7 g/dL) or β2-microglobulin (>3 mg/L), followed by the most important factor: the age of the ill (>65 years), are crucial for further proper risk assessment, according to the International prognostic scoring system for Waldenström macroglobulinemia (ISSWM) [5]. This evidence concerns the gene CD40LG and Waldenstrom macroglobulinemia.