The analysis data also showed that the patients also carried variants in genes associated with AVSD (e.g., COL11A1, DNAH11, GATA4, LRP2, MYH6, NFATC1, NKX2-6, NOTCH1, SRCAP, TBX1, and ZFPM2) [7,45,53,54,55], TGA (e.g., COL11A1, GDF1, LRP2, MYH6, and TBX1) [45,50,53,56], or hypoplastic left heart (e.g., LRP2, MYBPC3, MYH6, MYH7, and NOTCH1) [45,57,58,59,60]. The gene discussed is COL11A1; the disease is familial atrioventricular septal defect.