In melanoma cases, PRAME expression of ≥75% was observed in 8 of 12 metastatic melanomas (66.7%), 7 of 10 SSM (70%), 4 of 5 NM (80%), 9 of 10 LM (90%), and in all cases of ALM, LMM and mucosal melanomas (100%). This evidence concerns the gene PRAME and mucosal melanoma.