BTK and X-linked agammaglobulinemia: For instance, BTK p.Lys430Glu (catalytic Lys) abolishes kinase activity, leading to X-linked agammaglobulinemia, a rare genetic disorder characterised by the body’s inability to produce normal B cells [42], and DAPK3 p.Asp161Asn (in the DFG motif) greatly reduces kinase activity, promoting cell survival and cell proliferation in ovarian mucinous carcinoma [43].