For example, in IKBKB p.Ser181Glu, mutating the uncharged Serine to a negative charge leads to full activation of its kinase activity and activation of the NF-kappa-B pathway [44], while LATS2 p.Ser872Ala (at the equivalent alignment position), mutating the phosphorylatable Serine to an unphosphorylatable Alanine, is reported to lead to loss of its tumour suppressor activity in mice [45]. This evidence concerns the gene IKBKB and neoplasm.