For example, zinc finger E-box-binding homeobox 1 (ZEB1) promotes hepatocellular carcinoma (HCC) proliferation by activating the expression of muscle isoform of phosphofructokinase-1 (PFKM), a key enzyme in the Warburg effect, leading to enhanced glycolysis and elevated lactate levels. The gene discussed is PFKM; the disease is hepatocellular carcinoma.