HIF1A and neoplasm: In breast cancer, TAMs transfer the myeloid-specific long non-coding RNA, HIF-1α-stabilizing long noncoding RNA (HISLA), to tumor cells via extracellular vesicles, augmenting glycolysis and apoptosis resistance; conversely, tumor-derived lactate upregulates HISLA in TAMs, establishing a feedforward loop that reinforces tumor progression [90].