CAFs-derived lactate is imported into tumor cells via MCT1 and induces lactylation of anthrax toxin receptor 1 (ANTXR1) at K453, which stabilizes ANTXR1 and activates the RhoC/ROCK1/SMAD5 pathway, thereby enhancing cancer stemness and driving oxaliplatin resistance [138]. Here, SLC16A1 is linked to cancer.