In cisplatin-resistant non-small cell lung cancer (NSCLC) cells, elevated lactate levels suppress the expression of Forkhead box O3 (FOXO3) through YTH N6-methyladenosine RNA binding protein 2 (YTHDF2)-mediated N6-methyladenosine (m6A) modification. Here, FOXO3 is linked to non-small cell lung carcinoma.