ACE and Gaucher disease: Although various blood biomarkers—including chitotriosidase, chemokine ligand-18/pulmonary activation-regulated chemokine (CCL18/PARC), ferritin, angiotensin-converting enzyme (ACE), and tartrate-resistant acid phosphatase (TRAP) are commonly elevated in Gaucher disease (GD) (Fig. 1) but few are monospecific for GD [47–50].