There is evidence that Parkinson’s disease is strongly linked to disordered lysosomal function, and while the suggested relationship of the neurological disease to the metabolism of sphingolipids is unclear, apart from increasing age, mutations in GBA, the casual gene in Gaucher disease, are the strongest genetic determinants of this neurodegenerative syndrome in populations across the world [95–99]. Here, GBA1 is linked to Parkinson disease.