Moreover, when other antioxidant-related gene polymorphisms (SOD2, SOD3, PON1, and GSTT1) are present, GPX3 rs3828599 is more strongly associated with the incidence of hypertension and is positively associated with coronary artery disease and with the severity of coronary atherosclerosis [17, 18]. This evidence concerns the gene GPX3 and hypertensive disorder.