ALDOC and Alzheimer disease: Among the enzymes involved in glycolysis, ALDOC is essentially expressed by astrocytes (EWCE analysis, Fig. 1U) and its expression was reduced as early as the Braak IV stage (Braak IV vs CT: P = 0.0125; Braak VI vs CT: P = 0.0199, Fig. 1V) that may suggest that astrocytes play at least in part a role in the reduction of glycolysis in AD, as previously suggested [49, 50]