Similarly, important genes involved in calcium signaling (such as CALM1-3 and CALR) and inflammatory response genes (including IFNAR2, IRF7, CXCR2 or TNFRSF1A) also showed a substantial downregulation of H3K4me3 abundance in circulating neutrophils months after ARDS (Fig. 3f,g and Extended Data Fig. 3d). Here, CXCR2 is linked to acute respiratory distress syndrome.