In addition, this model is supported by the fact that a significant reduction in cardiac fibrosis after TAC was not seen in an independently established murine model of cardiac Fgf23 deletion with a slightly different experimental setting15, and that rFGF23 treatment did not regulate alkyl-DHAP in cultured rat neonatal cardiomyocytes in our study. This evidence concerns the gene FGF23 and persistent truncus arteriosus.