Those pathways which met the threshold requirement that is considered activated included several tumor suppression pathways (e.g., “p53 signaling”, “endocannabinoid cancer inhibition pathway”, while those pathways predicted to be inhibited included “ERK/MAPK signaling”, “PDGF signaling”, and “HGF signaling” (Supplementary Fig. 6B). The gene discussed is TP53; the disease is cancer.