In the pooled analysis, the final model showed significant associations between PGS predictors and the P.I. Specifically, extraversion, insomnia, interleukin-12p70, interleukin-16, multisite chronic pain, panic disorder, and total bilirubin were negatively correlated with the P.I., while hip circumference, ischemic stroke, and stroke were positively correlated. The gene discussed is IL16; the disease is stroke disorder.