In the pooled analysis, the final model showed significant associations between PGS predictors and the P.I. Specifically, extraversion, insomnia, interleukin-12p70, interleukin-16, multisite chronic pain, panic disorder, and total bilirubin were negatively correlated with the P.I., while hip circumference, ischemic stroke, and stroke were positively correlated. This evidence concerns the gene IL16 and Stroke.