TET1 and Prader-Willi syndrome: gRNAs-mCherry and dCas9-Suntag-TET1 components (dCas9-GCN4s and scFv-sfGFP-TET1CD) were delivered to organoids derived from PWS iPSCs by lentivirus and lipofection, respectively (Supplementary Fig. 12a, b).