In spontaneously hypertensive stroke‐prone rat models (SHRSP), the accumulation of Aβ and tau proteins was observed as the animals aged, indicating that hypertension‐associated small‐vessel disease may contribute to age‐related Aβ clearance impairment, elevated AβPP expression, and tau hyperphosphorylation in neurons.99 This evidence concerns the gene MAPT and hypertensive disorder.