STAT3 and neoplasm: Compared to most traditional metal complexes thattarget nucleicacids, organometallic complexes engaging with gene regulators providea novel approach to regulate abnormal gene expression. An early work focused on STAT3, which mediatesnumerous cellular responses, including interacting with tumor-associatedregulators. To minimize nonspecific interactionwith DNA, we developed polypyridyl-containing iridium and rhodiumcomplexes since the substituted N∧N ligand has arelatively inert nature (Figure B).