KDM1A and prostate cancer: Lysine-specific demethylase 1 (LSD1) is a key epigeneticregulatorthat dimethylates H3K4 and is linked to prostate cancer. LSD1 was targeted by rhodium­(III) complex 4 featuring 4-chloro-2-phenylquinoline C∧N ligands and a 4,4′-dimethoxy-2,2′-bipyridine N∧N ligand (Figure C). Structural optimizationrevealed that chlorination of the C∧N ligand (complex 4) enhanced LSD1 inhibition (over 10 times greater than thatof the dechlorinated analogue complex), likely due to improved hydrophobicand electronic interactions with the catalytic pocket.