The adverse prognostic significance of double expressor (DE) status—defined by co‐expression of MYC and BCL2—and double‐hit/triple‐hit (DH/TH) status—characterized by translocations involving MYC and BCL2 and/or BCL6—is well established in nodal diffuse large B‐cell lymphomas. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.