Increased nuclear concentration of HDAC4 has been observed in the brains of individuals with Alzheimer’s disease (AD) [28,29] and ataxia telangiectasia [30], as well as in mouse models of AD [28,31,32], CDKL5 disorder [7], 2q37 deletion syndrome [3] and Parkinson’s disease [33,34]. This evidence concerns the gene HDAC4 and Alzheimer disease.