While the precise mechanism by which Fgfr2 deficiency affects Fgfr1 and Fgfr4 mRNA expression remains unclear, a positive correlation between FGFR1 and FGFR2 expression has been documented in human laryngeal squamous cell carcinoma tissues (Hu & Zhang 2022). The gene discussed is FGFR4; the disease is laryngeal squamous cell carcinoma.