The dramatic differential gene expression between group A and B cancers was listed in Fig. 6A. The Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1), ADAM Metallopeptidase Domain 9 (ADAM9), Serpin Family A Member 3 (SERPINA3), Spermine Synthase (SMS), Lactate Dehydrogenase B (LDHB), Tumor Protein D52 (TPD52), and Secreted Frizzled Related Protein 1 (SFRP1) genes were highly expressed in post-treatment specimen (group A cancer), which are associated cellular metabolism, chemo-resistance or epithelial-mesenchymal transition pathway [[33], [34], [35], [36], [37], [38]]. This evidence concerns the gene SMS and cancer.