Pathogenic variants in SCN2A are implicated in a spectrum of neurodevelopmental disorders including developmental and epileptic encephalopathies (DEE), familial neonatal-infantile seizures (BFNIS), episodic ataxia, autism spectrum disorder (ASD), and intellectual disability (ID) with and without seizures [26]. This evidence concerns the gene SCN2A and developmental and epileptic encephalopathy.