KCNT1 and autosomal dominant nocturnal frontal lobe epilepsy: Pathogenic variants in KCNT1 can manifest as severe early-onset epileptic encephalopathies like malignant migrating focal seizures of infancy (EIMFS) and autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), often characterized by severe seizures with variable age of onset and cognitive impacts [66].