SCN2A and temporal lobe epilepsy: These results are consistent with studies of SCN2A patient-induced pluripotent stem cell (iPSC)-derived neurons demonstrating dysregulation of oxidative phosphorylation pathways and activation of calcium signaling and neurotransmission [112], as well as those showing a relationship between SCN2A expression and oxidative stress in the cortexes of patients with temporal lobe epilepsy [113].