The targeted augmentation of nuclear gene output (TANGO) approach, which uses ASOs to enhance expression of the functional allele, reduced intrinsic excitability of parvalbumin-positive (PV) inhibitory interneurons [150], and reduced both seizure frequency and SUDEP incidence in the Scn1a+/- models of DS [151] (Table 3). The gene discussed is PVALB; the disease is Dravet syndrome.