The 5′ UTR of casein kinase 1α (CK1α) mRNA functions as a putative IRES element in human carcinoma colorectal cancer cell lines (HCT)-116 colon cancer cells, such that silencing of SFPQ reduced CK1α protein abundance and partially blocked RAS-mutant colon cancer cell growth [66]. This evidence concerns the gene CSNK1A1 and malignant colon neoplasm.