RIPK1 and amyotrophic lateral sclerosis: RIPK1-dependent cell death has been closely associatedwith neurodegenerative diseases such as ALS, FTLD, and AD.−, ,  Structurally, RIPK1 features a distinctive hydrophobic pocket withinits kinase-regulating allosteric domain, making it an attractive targetfor pharmacological inhibition. The developmentof PET radiotracers in this area leverages the diverse pool of existingRIPK1 inhibitors.