PARP1-mediatedparthanatos has been increasingly recognized as a contributor to neuronalloss in various neurodegenerative diseases, including AD, PD, HD,and ALS., The involvement of PARP1 in both the DNArepair and parthanatos pathways underscores its dual-edged role inneuronal homeostasis and pathology. The gene discussed is PARP1; the disease is Alzheimer disease.