RIPK1-dependent cell death has been closely associatedwith neurodegenerative diseases such as ALS, FTLD, and AD.−, ,  Structurally, RIPK1 features a distinctive hydrophobic pocket withinits kinase-regulating allosteric domain, making it an attractive targetfor pharmacological inhibition. The developmentof PET radiotracers in this area leverages the diverse pool of existingRIPK1 inhibitors. This evidence concerns the gene RIPK1 and neurodegenerative disease.