PPARγ is amplified and upregulated (74) in PCa and BrCa cohorts (75) but is not commonly mutated (and it is not commonly targeted with therapies), and therefore PPARγ expression changes and lack of mutations may also reflect more nuanced functions of PPARγ in cancer cells, for example with roles in differentiation and cell metabolism. This evidence concerns the gene PPARG and invasive breast carcinoma.