IFNG and pachyonychia congenita: To examine the impact of SAT2 on diverse PC immune subtypes, we utilized the TISIDB database, which classifies tumors into six immune subtypes: C1 (wound healing), C2 (IFN-γ dominant), C3 (inflammatory), C4 (lymphocyte-depleted), C5 (immunologically quiet), and finally, C6 (TGF-β dominant) [16].