INS and liver disorder: Notably, two DEPs (up-regulated in SGA), namely PCYOX1 (related to adipogenesis) and HSP90AA1 (related to lipid metabolism and metabolic-dysfunction-associated steatotic liver disease progression) were independent predictors of the hepatic fat fraction at age 7 before the emergence of clinically overt metabolic alterations, such as increased insulin resistance and hepatic fat accumulation.