The diagnosis is preferably confirmed by histopathological evaluation (the reference standard) or supported by persistently elevated alanine aminotransferase (ALT) levels—exceeding twice the upper limit of normal for sex—alongside at least one of the following: excess adiposity, prediabetes or type 2 diabetes mellitus (T2DM), or at least two metabolic risk abnormalities (e.g., increased waist circumference, hypertension, hypertriglyceridemia, low HDL cholesterol, impaired fasting glucose, or elevated triglyceride-to-HDL-C ratio) [38]. This evidence concerns the gene GPT and hypertensive disorder.