Regarding lncRNA expression, the current study revealed a significant downregulation of HAR1B, MEG3, HOTTIP, and HOTAIR expression following combined treatments with SAHA + Pxl, SAHA + Qct, 5-Aza-C + Pxl, and 5-Aza-C + Qct, indicating the involvement of these epigenetic modulators in the suppression of oncogenic lncRNAs in thyroid cancer cells. Here, MEG3 is linked to thyroid gland carcinoma.