By integrating these criteria, we identified ten key proteins (Figure 2) (EGFR, ESR1, HIF1A, HSP90AA1, MAPK1, BCL2, STAT3, TP53, CASP3, and SRC) that play central roles in tumor progression and are therefore considered crucial therapeutic targets for rosemary-derived compounds. The gene discussed is ESR1; the disease is neoplasm.