Elevated IL-8 (≥20.28 pg/mL) increased the odds of T2D 6.7-fold (OR = 6.733; 95% CI: 3.307–13.709; p < 0.001), while IL-6 (≥7.465 pg/mL) and leptin (≥3.605 ng/mL) were also significant predictors (OR = 4.436 and 13.765, respectively; p < 0.001). Here, CXCL8 is linked to type 2 diabetes mellitus.