The study demonstrated that 15 signaling pathways could be impacted by methylation.In 21 genes that had differential methylation profiles, collagen type IV alpha 1 and alpha 2 genes showed hypomethylation.Methionine levels were elevated in cells from the Fabry patient.The study also demonstrated that abnormalities in glycolipid metabolism affect DNA methylation in patients with Fabry disease. The gene discussed is COL4A1; the disease is Fabry disease.