CYP2R1 and hypertensive disorder: Local research has reported the relation of CYP2R1 with tuberculosis [15], CYP27B1 with polycystic ovarian syndrome [16], the GC polymorphism with VDD (rs7041, rs4588), GC with asthma [17], GC with type 2 diabetes [18], and GC with acute myocardial infarction [19], while a single study reported that CYP2R1 polymorphisms (rs10766197 and rs10741657), VDR polymorphisms (rs2228570 and rs7975232), and CYP27B1 genetic variants (rs10877012) are associated with VDD and conditions such as hypertension and diabetes mellitus [20].