Based on Malwina Lisek et al. 2024 [31] and Na Yu et al. 2019 [32], the oncogene c-Myc, a member of the MYCN family of genes that regulate several genes associated with proliferation, metastasis, and cell survival was underexpressed in the Wageningen–Erlangen (WERI)-RB1 and Y79 cases, even though it is typically overexpressed in various types of cancer. This evidence concerns the gene RB1 and cancer.