MAPK8 and androgenetic alopecia: Among escin-mediated activation of the pathways, Wnt/β-catenin and JNK signaling (Figure 1 and Figure 2) are especially implicated in cutaneous diseases like androgenetic alopecia, premature hair graying, and edema, all of which are closely related to the quality of life of affected patients [59,60,61,62,63,64].