PTK2 and depressive symptom measurement: MR-Egger regression revealed no significant pleiotropy (p > 0.05 for all intercepts): “Antidepressant”: JUN intercept = 0.0034 (p = 0.622), PTK2 intercept = −0.0025 (p = 0.736); “Depression–dysthymia”: JUN intercept = −0.009 (p = 0.123), PTK2 intercept = 0.0013 (p = 0.836); Cochran’s Q-test indicated no heterogeneity (All p > 0.05): “Antidepressant”: JUN (p = 0.729), PTK2 (p = 0.265); “Depression–dysthymia”: JUN (p = 0.722), PTK2 (p = 0.484).