With aging, the Fth1/Ftl1 ratio increases, accompanied by a shift of Fth1 to fine processes, whereas in Alzheimer’s disease, this ratio decreases, redistributing Fth1 to the soma and Ftl1 to large processes near amyloid beta (Aβ) deposits [80]. This evidence concerns the gene FTH1 and early-onset autosomal dominant Alzheimer disease.